From every ancient source, we have testimony to Cleopatra's irresistible charm, as Plutarch has it, to her ability to speak many languages including, as he puts it, the language of flattery and essentially, to be able to turn people to her will - really a great political genius, in that respect.

Here you have an incredibly ambitious, accomplished woman who comes up against some of the same problems that women in power come up against today. Cleopatra plays an oddly pivotal role in world history as well; in her lifetime, Alexandria is the center of the universe, Rome is still a backwater.

For the several thousands of years before they became firefighters and physicians, women were sirens, enchantresses, snares. At times it seems as if female powerlessness is male self-preservation in disguise. And for millennia, this has made for a zero-sum game: A woman's intelligence was a man's deception.

Recently a study proved that working from a larger, less cluttered computer screen increases concentration. I could have told them that. And yes, I write first drafts with a mechanical pencil and a yellow legal pad. There's good reason for this primitive behavior: I am a crackerjack typist. My hand moves far more quickly than my brain.

For a few thousand years, women had no history. Marriage was our calling, and meekness our virtue. Over the last century, in stuttering succession, we have gained a voice, a vote, a room, a playing field of our own. Decorously or defiantly, we now approach what surely qualifies as the final frontier.

I can't write a line without music - it provides just the right amount of distraction to keep me focused. Clearly, I still miss the noisy roommates.

When finally I mustered the courage to tell a novelist friend that I was talking to editors about a biography, her reply was, 'Oh, that's okay. That's not a real book.'

Life-writing calls for any number of dubious gifts: A touch of O.C.D., a lack of imagination, a large desk, neutrality of Swiss proportions, tactlessness, a high tolerance for archival dust. Most of all it calls for an act of displacement. 'To find your subject, you must in some sense lose yourself along the way,' is Richard Holmes's version.